Stuart Gray - Omega 3s, Muscle Function and Ageing

This week Mikki sits down with Dr Stuart Gray from the University of Glasgow to talk about the impact that omega 3 fatty acids have on muscle health and function in an ageing population (and why it matters).

Dr Stuart Gray graduated from the University of Glasgow with a BSc in Physiology and Sports Science and subsequently completed a PhD in Exercise Physiology from the University of Strathclyde. After post-doctoral positions at Strathclyde and Loughborough Stuart was appointed to Lectureship at the University of Aberdeen. In 2015 he took up a position in the Institute of Cardiovascular and Medical Science (ICAMS) at the University of Glasgow.

In this week’s episode, Mikki and Dr Gray talk about:

·        His professional career from exercise physiology to ageing populations and the impact of omega 3s on ageing muscle.
·        Dietary guideline recommendations that don’t reflect changing needs with different age groups
·        The epidemiological research that shows associations between fatty fish and healthy ageing
·        The animal (pre-clinical) trials that act as proof of concept of omega 3 fatty acid’s impact on muscle function and health
·        The randomised clinical trials in an ageing population that show with (and without exercise) the benefit of taking omega 3 fatty acids
·        The differing impact between krill oil and standard omega 3 fatty acids
·        Suggested dosage of omega 3 fatty acids
·        The potential mechanisms for how omega 3 fatty acids influence muscle health
·        The potential for omega 3 fatty acids to really benefit those who are not healthy, including people with type 2 diabetes

Papers discussed (or related to discussion):

Robinson SM, Jameson KA, Batelaan SF, Martin HJ, Syddall HE, Dennison EM, Cooper C, Sayer AA; Hertfordshire Cohort Study Group. Diet and its relationship with grip strength in community-dwelling older men and women: the Hertfordshire cohort study. J Am Geriatr Soc. 2008 Jan;56(1):84-90. doi: 10.1111/j.1532-5415.2007.01478.x. Epub 2007 Nov 15. PMID: 18005355; PMCID: PMC2493054.

Da Boit M, Sibson R, Sivasubramaniam S, Meakin JR, Greig CA, Aspden RM, Thies F, Jeromson S, Hamilton DL, Speakman JR, Hambly C, Mangoni AA, Preston T, Gray SR. Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: a randomized controlled trial. Am J Clin Nutr. 2017 Jan;105(1):151-158. doi: 10.3945/ajcn.116.140780. Epub 2016 Nov 16. PMID: 27852617; PMCID: PMC5183731.

Da Boit M, Mastalurova I, Brazaite G, McGovern N, Thompson K, Gray SR. The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function. PLoS One. 2015 Sep 25;10(9):e0139174. doi: 10.1371/journal.pone.0139174. PMID: 26407095; PMCID: PMC4583249.

Kamolrat T, Gray SR, Thivierge MC. Fish oil positively regulates anabolic signalling alongside an increase in whole-body gluconeogenesis in ageing skeletal muscle. Eur J Nutr. 2013 Mar;52(2):647-57. doi: 10.1007/s00394-012-0368-7. Epub 2012 May 13.PMID: 22581256.

McGlory, C., Calder, P. C., & Nunes, E. A. (2019). The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease. Frontiers in nutrition, 6, 144.

Mcglory, C., Gorissen, S.H.M., Kamal, M., Bahniwal, R., Hector, A.J., Baker, S.K., Chabowski, A. and Phillips, S.M. (2019), Omega‐3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobilization in healthy young women. Faseb, 33: 4586-4597.

Tipton KD. Nutritional Support for Exercise-Induced Injuries. Sports Med. 2015 Nov;45 Suppl 1:S93-104. doi: 10.1007/s40279-015-0398-4. PMID: 26553492; PMCID: PMC4672013.