Dr. Dom D’Agostino - Allulose, Ketogenic Diets, and Metabolic Health: On the Cutting Edge of Nutrition Science

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Today on the podcast, Mikki speaks to Dr. Dom D’Agostino, a leading researcher in metabolic health, ketogenic diets, and performance optimization. Dom has been at the forefront of exploring how nutrition—particularly low-carb and ketogenic strategies—impacts brain health, endurance performance, cancer metabolism, and longevity.

In this episode, he and Mikki dive into two major topics that have been gaining traction in the health and nutrition space: allulose as a metabolic sweetener and the latest research on the ketogenic diet’s effects on lipids, gut health, and glucose metabolism.

They begin by unpacking allulose, a rare sugar that’s rapidly growing in popularity within the low-carb and metabolic health community. Dom has conducted extensive n=1 experiments on this sweetener and has shared his insights widely on social media. He explains how allulose differs from traditional sweeteners, its impact on blood sugar, insulin, and GLP-1, and whether it could be a game-changer for metabolic health. They also discuss how the FDA’s labeling decision influences consumer perception and what role allulose might play in future dietary strategies.

The conversation then shifts to the ketogenic diet, exploring a recent study that examined its effects on metabolic health, gut microbiome, and cardiovascular markers. Some of the findings—such as increased ApoB and transient inflammation—have sparked debate, and Dom provides his perspective on what these results actually mean. He and Mikki also discuss the implications of gut microbiome shifts, the potential concerns around glucose tolerance, and how to fine-tune a ketogenic approach for long-term health.

For anyone interested in the cutting edge of metabolic science—whether it’s the role of emerging sweeteners or the nuances of ketogenic diets—this episode is packed with valuable insights.

Dr. Dominic D’Agostino is a leading researcher in the fields of metabolic health, ketogenic nutrition, and performance science. As an Associate Professor at the University of South Florida in the Department of Molecular Pharmacology and Physiology, his work focuses on the neuroprotective and therapeutic applications of ketogenic diets, exogenous ketones, and metabolic therapies for conditions such as epilepsy, cancer, and neurodegenerative diseases.
Dr. D’Agostino’s research spans human performance, space medicine, and metabolic resilience, with collaborations extending to NASA, the Department of Defense, and leading medical institutions. His work has explored how ketogenic and fasting-based strategies can enhance physical and cognitive function under extreme conditions, from deep-sea diving to spaceflight.
In addition to his academic and research work, he is widely recognized for his expertise in low-carb and ketogenic science, frequently sharing insights on his podcast appearances, social media, and public talks. He has conducted extensive n=1 experiments on metabolic biomarkers, dietary interventions, and the effects of ketones and alternative sweeteners like allulose, helping to bridge the gap between scientific research and real-world application.
Dr. D’Agostino is also on the editorial board of multiple scientific journals, has published extensively in peer-reviewed literature, and is a sought-after speaker in the areas of metabolic health, longevity, and human optimization. His work continues to push the boundaries of what’s possible in nutrition science and metabolic therapies

Metabolic Health Summit https://metabolichealthsummit.com/

Creators and Guests

Mikki Williden
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Mikki Williden
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