The Case for Intervention: Peptides, GLP-1s, and the World We Live In - Kyal Van Der Leest

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This week on the podcast, Mikki speaks to Kyal Van Der Leest, founder of LVLUP Health, for a wide-ranging and clinically grounded conversation on peptides, gut health, GLP-1s, and modern metabolic dysfunction. Kyal unpacks his core philosophy that many of today’s health challenges are predictable outcomes of the environments and lifestyles we now inhabit—and why targeted supplementation and protocols may be necessary to offset those exposures.

They explore peptides as a bridge between naturopathic and conventional medicine, including when they are appropriate, how delivery routes change outcomes, and how to differentiate common compounds like BPC-157, GHK, KPV, and lorazotide. They discuss  GLP-1 agonists—their risks, misconceptions, gut-motility paradoxes, and why “fixing the gut first” is non-negotiable, and much more.

Kyal Van Der Leest is a qualified Nutritionist, Naturopath, and functional health strategist with a deep-rooted passion for human optimisation and evidence-based supplementation. He is the founder and formulator behind LVLUP Health, a science-driven wellness brand dedicated to developing advanced practitioner-grade supplements that support the body’s innate healing systems. Kyal’s journey into health innovation began in clinical and retail environments—including hyperbaric oxygen therapy and high-volume supplement settings—where he saw firsthand the limitations of conventional products and protocols. This sparked his mission to create targeted formulations that combine clinically relevant compounds, peptides, and high-quality actives to simplify and enhance health outcomes. Today his products are stocked globally and recognised for their efficacy within both practitioner and biohacking communities. Beyond formulation, Kyal is known for his commitment to practical, mechanism-based approaches to gut health, inflammation, recovery, and longevity.