Fasting Claims, Collagen for Cellulite, and Who to Trust in Women's Health
Hey everybody, it's Mikki here. You're listening to Mini-Mikkipedia on a Monday, and today I just want to share my thoughts and feelings around other people in the women's health space.
You know, I am often asked how one might determine whether somebody is worth a follow and whether we should take what they're saying as being sort of useful information.
And I have to say that some people sort of appear on our screens and they seem pretty legit, but then when you get to the heart of what they're all about, it's actually just really to sell you stuff and prey on your insecurities and under the guise of trying to help you and lift you up.
And this is what absolutely grinds my gears, so I thought I'd do a little Mini-Mikkipedia on it.
So, you know, I just want to mention a couple of things.
You guys, I feel like you know how...
What I sort of think of...
I'm just going to say Dr. Mindy Peltz, right?
So she's got this whole system, fast like a girl, eat like a girl, age like a girl.
I'm not quite sure what her last book is called, actually.
And I was mildly curious as to the fasting like a girl, thinking that, you know, maybe she knows, she's come across research that others aren't familiar with.
And this was certainly in the, I suppose, maybe the height of my own interest in fasting as a healthist.
Which, I will say right now, eating has done so much more for me than fasting ever did as a very active 49-year-old woman.
However, I bought her book, I opened it up, and I started reading it.
And then I just started fact-checking all of the things that she was saying, and none of it came to fruition.
Much of the research that she cited was mechanistic, i.e. from like a test tube.
People...
People...
Or it was preclinical.
So they were rodent and mice models.
Now, these are very important ways with which research is conducted.
You know, you want to try and find a mechanism to then see how it plays out in a human clinical trial, if that is possible, because it isn't always.
But regardless, a lot of her research that she was drawing on was either mechanistic or preclinical, or just was plain wrong.
Like, a complete misunderstanding of how hormones worked.
And I've got friends who are very knowledgeable on hormones.
It's their absolute area of expertise.
And they were, like, shaking their heads in disbelief as to some of the claims that was being made.
Now, I'm often asked about Dr. Mindy Peltz's Fast Like a Girl, and there is absolutely nothing to support what she is talking about in the book.
And many individual clients have come to me to try to...
resolve some of their hormonal challenges and some of their challenges, and have questions about that fasting protocol, or who have said that they've done it.
And it's really just sort of put them in a bit of a metabolic hole.
I do wonder whether some of the information out there, it's just, it's reaching an audience that it should never reach.
So just to, I guess, back the truck up a little bit around the fasting thing.
So please don't misunderstand me in terms...
Or maybe I just wasn't clear.
So this is my, this is my take on fasting.
It is a very helpful therapeutic tool for someone who may be severely insulin resistant, for people who might have gut related issues.
And, you know, like there is certainly research around using fasting as a tool to help sensitize cancer cells to treatment and help protect healthy cells.
Dom D'Agostino talks a lot about that.
He's an absolute legend in research around ketogenic diets and fasting.
So, yeah, I think it's a really helpful tool.
I think it's a really helpful tool.
I think it's a really helpful tool.
I think it's a really helpful tool.
I think it's a really helpful tool.
Fasting therapies is adjuncts to your standard therapy.
But fasting as a rule for women who are active is just, don't think there's, I just think almost no one benefits from it, actually.
And I'm not talking about 12 hours.
I mean, 12 hours in and of itself shouldn't really be considered fasting.
Really, like if you're finishing dinner by 7pm and not having breakfast till like 8 the next morning, no big deal.
If you're...
If you're super active, you're probably better off having something before you train if you train in the morning.
So your eating window might actually be a little longer.
The benefits of exercise will far outweigh any potential benefit that an extended fasting window would give you anyway.
They're very similar in terms of the benefits you can get from fasting and exercise.
And if you are like me, who is very active, fasting will just put you in a metabolic hole way faster than you can imagine.
So, yeah.
Certainly not my go-to.
But I do know it has utility.
All that said, Mindy is another person.
Dr. Mindy is a person that just really, she toes the line between positioning herself as a super helpful person, putting out all of this free information.
But then just trying to make a buck, which obviously as a business person, I also want to make a living doing my business, doing what I love.
But I try to do it with integrity based on sound information.
And I just like, I just feel like this line.
It gets very easily blurred when you've got massive audiences and you are sort of spouting some information.
And Dr. Mindy also says that fasting increases growth hormone and therefore it's preserving muscle mass.
It raises, you know, testosterone and it, you know, in a good way.
And it helps protect muscle during a fast.
However, what you need to help build muscle and get that anabolic.
Switch is also a shift or an increase in IGF-1.
And IGF-1 actually needs protein and energy to help enhance its action or actually, you know, work properly.
So fasting actually lowers IGF-1.
So you might get this increase in growth hormone, but you're not getting the subsequent increase in IGF-1, which would therefore promote muscle building.
So fasting absolutely does not protect muscle the way that she says.
So that's just.
It's like completely false.
And I don't know whether it's just this ignorance as to how physiology works or if it's directly misleading people.
If you want the anabolic effects of growth hormone, you need IGF-1 and IGF-1 needs that protein and energy.
So, you know, she talks about these massive percentages of sort of increase between change, change from baseline to a change in growth hormone.
After a fast.
But those numbers are so, so incredibly small that it's more an artifact of dividing by a near zero baseline, actually.
So, yeah.
One last thing I will say about Dr. Mindy before turning my attention to someone else, just one other person, is and you guys know I'm hot on GLPs and I'm a huge fan of them.
And I really enjoy looking at the research and helping people sort of navigate that ever increasing field of work.
Weight loss because it's becoming much more popular.
Something else that Dr. Mindy says is that fasting raises GLP-1 and therefore you shouldn't need to and should not desire to take a medication because you can work with your body's own physiology and increase its own GLP-1.
So fasting does not and cannot raise GLP-1 because GLP-1 is a nutrient sensing hormone.
So I don't even know where this claim comes from.
So GLP-1, as you know, is secretive.
It's activated by enteroendocrine L-cells in the distal small intestine and colon in response to nutrients arriving in the gut lumen.
So protein, fat, fermentable fiber, these are the main triggers.
If you remove food, you remove that stimulus.
So if there is a pitch saying that your body produces a powerful fat burning hormone called GLP-1 and fasting activates it, the right food amplifies it.
Those second and third.
Clauses absolutely contradict each other.
The foods amplify it.
Absolutely.
The fasting is really like the absolute trough between each ability to amplify that GLP-1, i.e.
between every time you eat.
So what can be defended is that fasting or time restricted eating might improve that L-cell responsiveness so that when you do eat, you get a more robust GLP-1 signaling response.
But to claim that fasting enhances GLP-1 to the point that it acts like a medication, as she implies, is just flat out misleading and false.
And this is what she is selling.
And I just have to say that she's a smart woman.
My brain goes to, well, maybe she just doesn't realize that her physiology is wrong.
But actually, I don't believe that for a second.
Dr. Mindy is smart.
She has built an empire.
She has over.
A million, maybe even closer to 1.5 million women following her and taking her advice.
And she's deliberately misleading them to sell products.
And that is not done on the back of ignorance.
She is deliberately misleading them.
So that just really bloody, it just grinds my gears.
And the reason I got on this rant in the first place, which brings me to my second person.
And don't worry, it's not going to be that long.
It's bloody Dr. Mary-Claire Haver.
I just happened to land on an advert for her this morning that said that she'll never
forget the day that her daughter was complaining about her cellulite.
So she made it her mission to look into the research and find what it was that would help
her daughter resolve her cellulite.
And I'm like, what the hell?
And I see that Dr. Mary-Claire Haver, one of her best-selling supplements, is this mixture
of two different types of collagen, fortabone, and verisol.
Both of them have been attractive.
They're attributed as showing beneficial effects for both bone and for skin.
And so Dr. Mary-Claire's answer to her daughter's worries about her cellulite isn't to take
her aside and say, there are way more important things that you need to be worried about.
Let's focus on something meaningful.
Let's go for a run and have a workout and really discuss things that are going to help
further you and not burden yourself with these hyper-focus on some body part.
No, no.
She develops a supplement.
So that's my main, that's, you know, I have a big beef with that, actually.
Like, again, another woman who reports to be out there to lift women's health up and
to sort of be at the forefront of perimenopausal and menopausal woman challenges and help them
rise above this time in life and really thrive is, in a heartbeat, selling supplements because
we should all be worried about cellulite.
I've got the solution to your issue with cellulite.
It's her response rather than, shit, you do not need to be worried about cellulite.
Anyway, I went looking in the literature for this.
Now, ForteBone, amazing.
There's a lot of good clinical data to show its impacts on bone health, on tendon health.
There are clinical trials.
There's preclinical trials.
There are case studies.
You've got Mike Ormsby's lab who has found that in middle-aged athletes like us, it helps
reduce perception.
It helps relieve pain.
And so, I mean, that's a huge outcome if you are as active as we are.
So ForteBone, great.
Verisol is another type of collagen that's been studied for its impact on skin health.
And there has been one study, and it was 10 years ago in the Journal of Medicinal Food,
not sure what impact factor that has, on 105 women who have normal weight BMI, and they
had moderate cellulite.
I'm not sure how they determine what your cellulite.
And they were randomized to receive 2.5 grams of bioactive collagen peptides or a placebo
daily for six months.
And over the course of that six months, these women showed a 9% mean reduction in cellulite
scores versus the placebo.
Oh, I'm sorry.
I read that wrong.
In fact, there was a mixture of both normal weight BMI participants and participants with
a BMI over 25.
So that would place them in an overweight category.
And they, in fact, had a 4% decrease in cellulite, apparently, in cellulite score.
So there is one trial to show that the appearance of cellulite was reduced when you took 2.5
grams of these collagen peptides, that type that I just mentioned, Verisol.
The thing is, though, there has been one trial over the last 10 years, 11 years at this point.
Nothing has ever come close to replicating that.
And in fact, the wider collagen.
The literature apparently has a bit of a funding problem, and I didn't realize this.
Now, this is purely looking at the skin related information around collagen, which I was
actually like, oh, yeah, there's a lot of research on skin and how it can really help
improve the elasticity and the appearance of skin.
But you know what?
These researchers, Mayang and Parks, in 2025 in the American Journal of Medicine, they
pulled 23 randomized control trials with close to 1500 participants.
And whilst they found collagen significantly improved skin hydration, elasticity and wrinkles,
they also found that trials without pharmaceutical or supplement industry funding showed no
effect on any of those three things.
So the only trials that find benefit for collagen for skin are trials that are funded by the
manufacturers of those products.
So, look, we need funding and research.
Funding will come from everywhere.
So I'm not saying that.
I'm not suggesting, no, I am actually, I am suggesting that that's going to bias the
data to show that collagen is, in fact, helpful for skin.
I just think we need to take the skin related benefits to collagen with a grain of salt.
I'm not suggesting that you're not going to notice a benefit, but the research doesn't
really sort of support it.
And for what it's worth, if you are after the cellulite appearance benefits of collagen,
nine percent is probably not going to make a difference.
Actually, you're probably not going to notice a difference in your cellulite appearance if
nine percent is all you've got to work for.
And for what it's worth, two and a half grams of collagen is not that much compared to the
10 grams that Ormsby's lab used to help with that reduction in pain from that sort of
fortabone collagen.
So I like collagen.
I'm a little bit on the fence now about its benefits for skin.
And I 100 percent do not recommend you take collagen to help improve your appearance of
your cellulite.
Because I just really wish that you just didn't even care about that anyway.
Now, look, I am not in your body.
I do not know what you go through day to day.
So I do appreciate that fact.
But it's just such a meaningless, meaningless thing to worry about.
There are just so many other things that you could be thinking about other than the appearance
of your cellulite.
Like, think about this is a thing with women's health is that for decades, we have been worried
about body size, body shape, cellulite, how close.
All of these things.
And what about all the other things that we could be thinking about?
Like, I don't know, world peace or, you know, building the next something that's going to
like make our lives a whole lot more simple.
I don't know.
But this is something which has probably held women back for decades at this point.
So why are we even talking about cellulite now?
And I do think it's different.
You know, I did get some pushback from people when I posted about this on social media saying,
hey, Mikki, come on, you talk about women's bodies all of the time.
And that is true because I work with so many women who just want to feel better.
They want to look different.
They want to lean out and they want to feel good in their genes, et cetera.
And so everyone has these aesthetic goals.
And I'm here for the aesthetic goals, but I am not here for the hyper focus on things
that we can't do much about to then on the back of that sell you a supplement.
Like, I would never do that.
And I think it says something about a woman's health expert that they do.
I really do think that says something about them.
So if you want to know who you should follow in terms of things of women's health and who
is really there to lift up women, I don't think it's either of these two, actually.
I think you want to look to Hayley Happens, Hayley Babcock.
She's amazing.
She really cares about you.
Look for Dr.
Abby Smith-Ryan.
She absolutely just wants to lift women up.
And Stacey Sims, Dr.
Stacey has done a ton for women in the space.
And you will love her.
You will never hear these women talk about cellulite at all.
Like, it is the furthest thing from their mind.
But there are so many other people that I could name here.
Jen Kirsch, Holly Nicholson.
You know, I'm thinking about my business peeps.
I don't give a shit about cellulite and neither should you.
And you should certainly not buy that supplement.
And I'm not going to turn around and tell you to buy my supplement because I'm not going to make a supplement.
Like, I decided that a while ago, actually, that, you know, I've been approached several times.
And it's I just.
Don't think that I would.
I don't trust myself, actually, that I would be able to draw a line in the sand for being able to promote something which I with integrity and then make a buck on the side.
Like, I don't know.
Like, I don't just think it's such a blurred line.
And I just wouldn't want to be in the position where I had to sort of cross it or not, you know.
So anyway, these are my thoughts.
These are my thoughts on drifting in the woman's health space.
And these are just two very small examples.
There are probably a million.
There are a million others anyway.
So, you know, feel free to share your thoughts.
I don't you can totally disagree with me if you like.
I honestly, I'm just telling you what I what I think.
So I'm over on Instagram.
Threads and X at Mikki Williden.
I'm on Facebook at Mikki Williden nutrition.
We'll head to my website, Mikki Williden dot com.
Scroll down to the bottom, pop your name on the email list.
And and then you can get all of these thoughts and feelings and research and things that are actually backed by real data in your inbox every Monday.
Because that's what I'm about.
I'm about integrity.
I'm about lifting you up and making you be your best self.
Anyway, you guys have a great day.
See you later.